Notes From The Cutting Edge: Israeli Researcher Dedi Meiri On Cannabis, Alzheimer’s And Dementia

Israeli Cannabis researcher Dedi Meiri

RAANAN TAL

I recently listened to a webinar where David (Dedi) Meiri discussed the marijuana research study in his laboratory at the Technion-Israel Institute of Innovation. Meiri is best understood for his work matching specific parts of cannabis to affect various kinds of cancer. However when the job interviewer asked the Israeli researcher which locations of medication he believed marijuana used the most assure, the answer was surprising.

On top of what is already understood and dealt with … discomfort, sleep, epilepsy, stress and anxiety and these examples, I believe that a person of the important things that is still not being treated with marijuana … and I actually, truly think in it, and in my laboratory I have extraordinary results, is dementia and Alzheimer’s.

There is a large and growing body of anecdotal accounts of the effectiveness of marijuana for dealing with the signs of Alzheimer’s disease and dementia. The shortcomings and actual dangerous threats associated with basic and often prescribed pharmaceutical treatments for these conditions makes marijuana a particularly engaging choice– specifically considering its strong safety profile.

In a follow up Zoom call, Dedi discussed his deal with this subject:

First Off, marijuana is extremely helpful in enhancing lifestyle: lowering stress and anxiety, enhancing sleep, minimizing violence. We know it from our work with autistic kids, from treating PTSD, and other signs. We currently understand which stress are attaining this result and a lot of them are high CBD pressures, with extremely low or no THC. Autistic kids in Israel are getting a stress extract with a very low quantity of THC and it still lowers violence, truly improves sleep and decreases stress and anxiety.

If we’re discussing improving quality of life of the Alzheimer’s client and their households … people with Alzheimer’s typically experience bursts of anger and sleep disorders. So on that scale marijuana is extremely beneficial …

However Meiri likewise mentions that for Alzheimer’s disease, like with cancer, cannabis might likewise have a role beyond palliative care. Simply as his laboratory takes a look at the different chemovars and combinations of cannabinoids that can potentially apprehend cancer advancement, they are investigating the neuroprotective performance of these substances too.

With Alzheimer’s, on top of all the palliative treatment on the quality of life, there is a question whether cannabis can likewise truly combat the dementia or enhance the memory or the pathology of the illness itself. There are currently a couple of studies that have actually shown that cannabis in low dosages can be reliable.

Over the last three years, Meiri has been pursuing this line of research study using mouse and other Alzheimer’s disease models.

We screened a great deal of cannabis chemovars and defined a couple of that are reducing the amyloid plaques in the brain. We also determined the systems that are activated in the brain, how this occurs, and why they are decreasing the plaques. We have very strong outcomes revealing improvement in the pathology of the disease in mice with quite innovative Alzheimer’s after treatment with particular molecules of marijuana. This includes enhancements in the damage from the amyloid plaques in the brain and the neurons that were treated with the particular marijuana particles, in addition to enhancement in their habits as evidenced through numerous tests.

Nevertheless, there is a big space in between the mice brain and the human brain, so I couldn’t tell you if it will work in human clients …

To overcome that gap, Meiri and his team are now in the procedure of getting approvals for a medical trial to test the effects of a complete spectrum marijuana extract on patients.

It’s a medical trial on around 80 clients who suffer from serious Alzheimer’s disease, with violent behavior, anxiety, anger and sleep disorders. We will treat them with marijuana to see if it can enhance their habits, make them calmer, more unwinded and assist them sleep much better. This is cannabis with an extremely low amount of THC or without THC at all– a whole extract of a high CBD stress. So it’s not just sedation – you do not give them THC and get them stoned and they’re simply lying on the couch. It’s not that. It’s other compounds and other impacts.

We likewise discussed the essential nuances in between marijuana cultivars, and the requirement of looking beyond just THC and CBD.

We have cultivars that are improving a disease significantly, and we have cultivars that make the illness even worse, despite the fact that they have the same amount of CBD and THC. So there are other compounds which are effective or interfere with the treatment in various cultivars. And we see this in every kind of disease that we’re working on. It’s true for sleep conditions, numerous sclerosis, in Alzheimer’s and with a cancer. It’s true with psoriasis, and in whatever that my laboratory is doing. We see that there specify cultivars that are working, not working and ones that make things even worse. And you require to know how to select them.

If that holds true, then what about all the cannabis medicines that are just composed of THC and CBD isolates in different ratios?

I guess for particular indications, like pain, for example, it could be enough. However in a great deal of the indicators, it will not be enough. I can tell you that if you take a look at leukemia, what we discover is that if you just treat it with CBD you will get absolutely no response. The very same chooses several sclerosis, Alzheimer’s and even breast cancer … I have at least 6 different examples that I currently proved that it’s not the THC/CBD ratios, or it’s not enough. I can’t say that about whatever, but for sure in these sort of indications.

So after eliminating just CBD and THC, I asked him, what does he presume is making the difference?

I am 100%sure it’s not the THC and CBD due to the fact that I already removed them … however I’m still not truly sure about the rest. I’m believing that the flavonoids might be playing a huge function there … Just a couple of cannabinoids or households of cannabinoids, but mainly most likely flavonoids and terpenoids – give me a couple of more months and after that I’ll tell you.

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